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Robert Gatenby, MD

Co-Director, Center of Excellence for Evolutionary Therapy
DEPT CHAIR DIAGNOSTIC IMAGING

 
Specialty: Radiology
Program: Diagnostic Imaging and Interventional Radiology

Call 1-888-663-3488

Call 1-888-663-3488


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Overview

Bob received a B.S.E. in Bioengineering and Mechanical Sciences from Princeton University and an M.D. from the University of Pennsylvania. He completed his residency in radiology at the University of Pennsylvania where he also served as chief resident. Bob remains an active clinical radiologist specializing in body imaging.  While working at the Fox Chase Cancer Center after residency, Bob perceived that cancer biology and oncology were awash in data but lacked coherent frameworks of understanding to organize this information and integrate new results. Reaching back to his training in engineering and physical sciences, Bob recognized that cancer was a complex dynamic system (similar, for example, to weather) and that understanding the often non-linear interactions that govern such systems requires mathematical models and computer simulations.  As a result, most of Bob’s subsequent research has focused on exploring mathematical methods to understand the first principles and key parameters that govern cancer biology and treatment.  In 2008, Bob joined Moffitt as chair of radiology and convinced the leadership to add a group of mathematicians to the faculty and form the Integrated Mathematical Oncology (IMO) department. Now numbering 8 faculty mathematicians and over 20 post docs and grad students, the IMO  has catalyzed formation of several disease-oriented teams of oncologists, surgeons, pathologists, radiologists, mathematicians, physicists, cancer biologists, imaging scientists and evolutionary biologists.   These multidisciplinary groups are investigating virtually every aspect of cancer biology and therapy. In fact, IMO members are co-PIs of two ongoing clinical trials that use evolutionary dynamics and computational models to guide therapy. There is no other cancer center in the world that has so completely integrated mathematical modeling and computer simulations into basic science and clinical research.


Education & Training

Residency:

  • Hospital of U Penn - Radiology

Medical School:

  • University of Pennsylvania - MD
Awards
Start Year: 2014 End Year: 2015 W. Jackson Pledger Researcher of the Year Award, Sponsor: Moffitt Cancer Center
Start Year: 2016 End Year: 2017 Team Publication Award, Sponsor: Moffitt Cancer Center
Start Year: 2009 End Year: Highest Impact Factor Score Award, Sponsor: Moffitt Cancer Center
Start Year: 2009 End Year: Team Impact Publication Award, Sponsor: Moffitt Cancer Center
Participating Trials

If you believe you are eligible for one of these trials or studies, please call
813-745-6100 or toll-free 1-800-679-0775.

Publications

  • Pillai S, Mahmud I, Mahar R, Griffith C, Langsen M, Nguyen J, Wojtkowiak JW, Swietach P, Gatenby RA, Bui MM, Merritt ME, McDonald P, Garrett TJ, Gillies RJ. Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy. Cell Rep. 2022 May.39(6):110796. Pubmedid: 35545051. Pmcid: PMC9137419.
  • Jiang Q, Sudalagunta P, Silva MC, Canevarolo RR, Zhao X, Ahmed KT, Alugubelli RR, DeAvila G, Tungesvik A, Perez L, Gatenby R, Gillies R, Baz R, Meads MB, Shain KH, Silva AS, Zhang W. CancerCellTracker: A Brightfield Time-lapse Microscopy Framework for Cancer Drug Sensitivity Estimation. Bioinformatics. 2022 Jun. Pubmedid: 35751591.
  • Zhang J, Cunningham J, Brown J, Gatenby R. Evolution-based mathematical models significantly prolong response to abiraterone in metastatic castrate-resistant prostate cancer and identify strategies to further improve outcomes. Elife. 2022 Jun.11. Pubmedid: 35762577. Pmcid: PMC9239688.
  • Bukkuri A, Gatenby RA, Brown JS. GLUT1 production in cancer cells: a tragedy of the commons. NPJ Syst Biol Appl. 2022 Jun.8(1):22. Pubmedid: 35768428. Pmcid: PMC9243083.
  • Raja Arul GL, Toruner MD, Gatenby RA, Carr RM. Ecoevolutionary biology of pancreatic ductal adenocarcinoma. Pancreatology. 2022 Jul. Pubmedid: 35821188.
  • Prabhakaran S, Gatenbee C, Robertson-Tessi M, West J, Beg AA, Gray J, Antonia S, Gatenby RA, Anderson ARA. Mistic: An open-source multiplexed image t-SNE viewer. Patterns (N Y). 2022 Jul.3(7):100523. Pubmedid: 35845830. Pmcid: PMC9278502.
  • Bayer P, Gatenby RA, McDonald PH, Duckett DR, Staňková K, Brown JS. Coordination games in cancer. PLoS One. 2022 Jan.17(1):e0261578. Pubmedid: 35061724. Pmcid: PMC8782377.
  • Ben Ahmed K, Hall LO, Goldgof DB, Gatenby R. Ensembles of Convolutional Neural Networks for Survival Time Estimation of High-Grade Glioma Patients from Multimodal MRI. Diagnostics (Basel). 2022 Jan.12(2). Pubmedid: 35204436. Pmcid: PMC8871067.
  • Tomaszewski MR, Fan S, Garcia A, Qi J, Kim Y, Gatenby RA, Schabath MB, Tap WD, Reinke DK, Makanji RJ, Reed DR, Gillies RJ. AI-Radiomics Can Improve Inclusion Criteria and Clinical Trial Performance. Tomography. 2022 Feb.8(1):341-355. Pubmedid: 35202193. Pmcid: PMC8880510.
  • Ackerman RS, Luddy KA, Icard BE, Piñeiro Fernández J, Gatenby RA, Muncey AR. The Effects of Anesthetics and Perioperative Medications on Immune Function: A Narrative Review. Anesth Analg. 2021 Sep.133(3):676-689. Pubmedid: 34100781.
  • Brady-Nicholls R, Zhang J, Zhang T, Wang AZ, Butler R, Gatenby RA, Enderling H. Predicting patient-specific response to adaptive therapy in metastatic castration-resistant prostate cancer using prostate-specific antigen dynamics. Neoplasia. 2021 Sep.23(9):851-858. Pubmedid: 34298234. Pmcid: PMC8322456.
  • El-Kenawi A, Dominguez-Viqueira W, Liu M, Awasthi S, Abraham-Miranda J, Keske A, Steiner KK, Noel L, Serna AN, Dhillon J, Gillies RJ, Yu X, Koomen JM, Yamoah K, Gatenby RA, Ruffell B. Macrophage-Derived Cholesterol Contributes to Therapeutic Resistance in Prostate Cancer. Cancer Res. 2021 Nov.81(21):5477-5490. Pubmedid: 34301759. Pmcid: PMC8563406.
  • Pasetto S, Enderling H, Gatenby RA, Brady-Nicholls R. Intermittent Hormone Therapy Models Analysis and Bayesian Model Comparison for Prostate Cancer. Bull Math Biol. 2021 Nov.84(1):2. Pubmedid: 34797430. Pmcid: PMC8604892.
  • Pasetto S, Gatenby RA, Enderling H. Bayesian Framework to Augment Tumor Board Decision Making. JCO Clin Cancer Inform. 2021 May.5:508-517. Pubmedid: 33974446. Pmcid: PMC8240793.
  • Freischel AR, Damaghi M, Cunningham JJ, Ibrahim-Hashim A, Gillies RJ, Gatenby RA, Brown JS. Frequency-dependent interactions determine outcome of competition between two breast cancer cell lines. Sci Rep. 2021 Mar.11(1):4908. Pubmedid: 33649456. Pmcid: PMC7921689.
  • Grove O, Berglund AE, Schabath MB, Aerts HJWL, Dekker A, Wang H, Velazquez ER, Lambin P, Gu Y, Balagurunathan Y, Eikman E, Gatenby RA, Eschrich S, Gillies RJ. Correction: Quantitative Computed Tomographic Descriptors Associate Tumor Shape Complexity and Intratumor Heterogeneity with Prognosis in Lung Adenocarcinoma. PLoS One. 2021 Mar.16(3):e0248541. Pubmedid: 33684181. Pmcid: PMC7939347.
  • Artzy-Randrup Y, Epstein T, Brown JS, Costa RLB, Czerniecki BJ, Gatenby RA. Novel evolutionary dynamics of small populations in breast cancer adjuvant and neoadjuvant therapy. NPJ Breast Cancer. 2021 Mar.7(1):26. Pubmedid: 33707440. Pmcid: PMC7952601.
  • Capp JP, DeGregori J, Nedelcu AM, Dujon AM, Boutry J, Pujol P, Alix-Panabières C, Hamede R, Roche B, Ujvari B, Marusyk A, Gatenby R, Thomas F. Group phenotypic composition in cancer. Elife. 2021 Mar.10. Pubmedid: 33784238. Pmcid: PMC8009660.
  • Mason NT, Burkett JM, Nelson RS, Pow-Sang JM, Gatenby RA, Kubal T, Peabody JW, Letson GD, McLeod HL, Zhang J. Budget Impact of Adaptive Abiraterone Therapy for Castration-Resistant Prostate Cancer. Am Health Drug Benefits. 2021 Mar.14(1):15-20. Pubmedid: 33841621. Pmcid: PMC8025923.
  • Felder SI, Fleming JB, Gatenby RA. Treatment-induced evolutionary dynamics in nonmetastatic locally advanced rectal adenocarcinoma. Adv Cancer Res. 2021 Jun.151:39-67. Pubmedid: 34148619.
  • Dujon AM, Capp JP, Brown JS, Pujol P, Gatenby RA, Ujvari B, Alix-Panabières C, Thomas F. Is There One Key Step in the Metastatic Cascade?. Cancers (Basel). 2021 Jul.13(15). Pubmedid: 34359593. Pmcid: PMC8345184.
  • Ibrahim-Hashim A, Luddy K, Abrahams D, Enriquez-Navas P, Damgaci S, Yao J, Chen T, Bui MM, Gillies RJ, O'Farrelly C, Richards CL, Brown JS, Gatenby RA. Artificial selection for host resistance to tumour growth and subsequent cancer cell adaptations: an evolutionary arms race. Brit J Cancer. 2021 Jan.124(2):455-465. Pubmedid: 33024265. Pmcid: PMC7852689.
  • Zhang J, Cunningham JJ, Brown JS, Gatenby RA. Response to Mistry. Nat Commun. 2021 Jan.12(1):329. Pubmedid: 33436553. Pmcid: PMC7804311.
  • Damaghi M, West J, Robertson-Tessi M, Xu L, Ferrall-Fairbanks MC, Stewart PA, Persi E, Fridley BL, Altrock PM, Gatenby RA, Sims PA, Anderson ARA, Gillies RJ. The harsh microenvironment in early breast cancer selects for a Warburg phenotype. Proc Natl Acad Sci U S A. 2021 Jan.118(3). Pubmedid: 33452133. Pmcid: PMC7826394.
  • Strobl MAR, West J, Viossat Y, Damaghi M, Robertson-Tessi M, Brown JS, Gatenby RA, Maini PK, Anderson ARA. Turnover Modulates the Need for a Cost of Resistance in Adaptive Therapy. Cancer Res. 2021 Feb.81(4):1135-1147. Pubmedid: 33172930. Pmcid: PMC8455086.
  • Kareva I, Luddy KA, O'Farrelly C, Gatenby RA, Brown JS. Predator-Prey in Tumor-Immune Interactions: A Wrong Model or Just an Incomplete One?. Front Immunol. 2021 Aug.12:668221. Pubmedid: 34531851. Pmcid: PMC8438324.
  • Persi E, Wolf YI, Horn D, Ruppin E, Demichelis F, Gatenby RA, Gillies RJ, Koonin EV. Mutation-selection balance and compensatory mechanisms in tumour evolution. Nat Rev Genet. 2021 Apr.22(4):251-262. Pubmedid: 33257848.
  • Persi E, Wolf YI, Horn D, Ruppin E, Demichelis F, Gatenby RA, Gillies RJ, Koonin EV. Publisher Correction: Mutation-selection balance and compensatory mechanisms in tumour evolution. Nat Rev Genet. 2021 Apr.22(4):263. Pubmedid: 33318707.
  • Dujon AM, Aktipis A, Alix-Panabières C, Amend SR, Boddy AM, Brown JS, Capp JP, DeGregori J, Ewald P, Gatenby R, Gerlinger M, Giraudeau M, Hamede RK, Hansen E, Kareva I, Maley CC, Marusyk A, McGranahan N, Metzger MJ, Nedelcu AM, Noble R, Nunney L, Pienta KJ, Polyak K, Pujol P, Read AF, Roche B, Sebens S, Solary E, Staňková K, Swain Ewald H, Thomas F, Ujvari B. Identifying key questions in the ecology and evolution of cancer. Evol Appl. 2021 Apr.14(4):877-892. Pubmedid: 33897809. Pmcid: PMC8061275.
  • Azimzade Y, Saberi AA, Gatenby RA. Superlinear growth reveals the Allee effect in tumors. Phys Rev E. 2021 Apr.103(4-1):042405. Pubmedid: 34005934.
  • Ardaševa A, Anderson ARA, Gatenby RA, Byrne HM, Maini PK, Lorenzi T. Comparative study between discrete and continuum models for the evolution of competing phenotype-structured cell populations in dynamical environments. Phys Rev E. 2020 Oct.102(4-1):042404. Pubmedid: 33212726.
  • Gatenby RA, Brown JS. Integrating evolutionary dynamics into cancer therapy. Nat Rev Clin Oncol. 2020 Nov.17(11):675-686. Pubmedid: 32699310.
  • Gatenby R, Brown J. Retraction: The Evolution and Ecology of Resistance in Cancer Therapy. Cold Spring Harb Perspect Med. 2020 Nov.10(11). Pubmedid: 33139406. Pmcid: PMC7605237.
  • Gatenby RA, Brown JS. The Evolution and Ecology of Resistance in Cancer Therapy. Cold Spring Harb Perspect Med. 2020 Nov.10(11). Pubmedid: 33139405. Pmcid: PMC7605238.
  • Whitmire P, Rickertsen CR, Hawkins-Daarud A, Carrasco E, Lorence J, De Leon G, Curtin L, Bayless S, Clark-Swanson K, Peeri NC, Corpuz C, Lewis-de Los Angeles CP, Bendok BR, Gonzalez-Cuyar L, Vora S, Mrugala MM, Hu LS, Wang L, Porter A, Kumthekar P, Johnston SK, Egan KM, Gatenby R, Canoll P, Rubin JB, Swanson KR. Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients. BMC Cancer. 2020 May.20(1):447. Pubmedid: 32429869. Pmcid: PMC7238585.
  • El-Kenawi A, Gatenbee C, Robertson-Tessi M, Bravo R, Dhillon J, Balagurunathan Y, Berglund A, Vishvakarma N, Ibrahim-Hashim A, Choi J, Luddy K, Gatenby R, Pilon-Thomas S, Anderson A, Ruffell B, Gillies R. Correction: Acidity promotes tumour progression by altering macrophage phenotype in prostate cancer. Brit J Cancer. 2020 Mar.122(7):1118. Pubmedid: 31937927. Pmcid: PMC7109119.
  • Reed DR, Metts J, Pressley M, Fridley BL, Hayashi M, Isakoff MS, Loeb DM, Makanji R, Roberts RD, Trucco M, Wagner LM, Alexandrow MG, Gatenby RA, Brown JS. An evolutionary framework for treating pediatric sarcomas. Cancer. 2020 Jun.126(11):2577-2587. Pubmedid: 32176331. Pmcid: PMC7318114.
  • Ardaševa A, Gatenby RA, Anderson ARA, Byrne HM, Maini PK, Lorenzi T. A Mathematical Dissection of the Adaptation of Cell Populations to Fluctuating Oxygen Levels. Bull Math Biol. 2020 Jun.82(6):81. Pubmedid: 32556703.
  • Subramanian H, Gatenby RA. Evolutionary advantage of anti-parallel strand orientation of duplex DNA. Sci Rep. 2020 Jun.10(1):9883. Pubmedid: 32555277. Pmcid: PMC7303137.
  • Subramanian H, Brown J, Gatenby R. Prebiotic competition and evolution in self-replicating polynucleotides can explain the properties of DNA/RNA in modern living systems. BMC Evol Biol. 2020 Jun.20(1):75. Pubmedid: 32590933. Pmcid: PMC7318430.
  • Dujon AM, Gatenby RA, Bramwell G, MacDonald N, Dohrmann E, Raven N, Schultz A, Hamede R, Gérard AL, Giraudeau M, Thomas F, Ujvari B. Transmissible Cancers in an Evolutionary Perspective. iScience. 2020 Jul.23(7):101269. Pubmedid: 32592998. Pmcid: PMC7327844.
  • Enderling H, Altrock PM, Andor N, Basanta D, Brown JS, Gatenby RA, Marusyk A, Rejniak KA, Silva A, Anderson ARA. High School Internship Program in Integrated Mathematical Oncology (HIP IMO): Five-Year Experience at Moffitt Cancer Center. Bull Math Biol. 2020 Jul.82(7):91. Pubmedid: 32648152.
  • Whelan CJ, Avdieiev SS, Gatenby RA. Insights From the Ecology of Information to Cancer Control. Cancer Control. 2020 Jul.27(3). Pubmedid: 32762341. Pmcid: PMC7791475.
  • Muncey AR, Patel SY, Whelan CJ, Ackerman RS, Gatenby RA. The Intersection of Regional Anesthesia and Cancer Progression: A Theoretical Framework. Cancer Control. 2020 Jan.27(1). Pubmedid: 33070618. Pmcid: PMC7791454.
  • Whelan CJ, Gatenby RA. Special Collection on Ecological and Evolutionary Approaches to Cancer Control: Cancer Finds a Conceptual Home. Cancer Control. 2020 Jan.27(1). Pubmedid: 33054362. Pmcid: PMC7791469.
  • Ardaševa A, Gatenby RA, Anderson ARA, Byrne HM, Maini PK, Lorenzi T. Evolutionary dynamics of competing phenotype-structured populations in periodically fluctuating environments. J Math Biol. 2020 Feb.80(3):775-807. Pubmedid: 31641842. Pmcid: PMC7028828.
  • Gatenby RA, Artzy-Randrup Y, Epstein T, Reed DR, Brown JS. Eradicating Metastatic Cancer and the Eco-Evolutionary Dynamics of Anthropocene Extinctions. Cancer Res. 2020 Feb.80(3):613-623. Pubmedid: 31772037. Pmcid: PMC7771333.
  • Park DS, Luddy KA, Robertson-Tessi M, O'Farrelly C, Gatenby RA, Anderson ARA. Searching for Goldilocks: How Evolution and Ecology Can Help Uncover More Effective Patient-Specific Chemotherapies. Cancer Res. 2020 Dec.80(23):5147-5154. Pubmedid: 32934022.
  • Cunningham J, Thuijsman F, Peeters R, Viossat Y, Brown J, Gatenby R, Staňková K. Optimal control to reach eco-evolutionary stability in metastatic castrate-resistant prostate cancer. PLoS One. 2020 Dec.15(12):e0243386. Pubmedid: 33290430. Pmcid: PMC7723267.
  • Zahir N, Sun R, Gallahan D, Gatenby RA, Curtis C. Characterizing the ecological and evolutionary dynamics of cancer. Nat Genetics. 2020 Aug.52(8):759-767. Pubmedid: 32719518.
  • Gatenby RA, Avdieiev S, Tsai KY, Brown JS. Integrating genetic and nongenetic drivers of somatic evolution during carcinogenesis: The biplane model. Evol Appl. 2020 Aug.13(7):1651-1659. Pubmedid: 32952610. Pmcid: PMC7484850.
  • West J, You L, Zhang J, Gatenby RA, Brown JS, Newton PK, Anderson ARA. Towards Multidrug Adaptive Therapy. Cancer Res. 2020 Apr.80(7):1578-1589. Pubmedid: 31948939. Pmcid: PMC7307613.
  • Sudalagunta P, Silva MC, Canevarolo RR, Alugubelli RR, DeAvila G, Tungesvik A, Perez L, Gatenby R, Gillies R, Baz R, Meads MB, Shain KH, Silva AS. A pharmacodynamic model of clinical synergy in multiple myeloma. EBioMedicine. 2020 Apr.54:102716. Pubmedid: 32268267. Pmcid: PMC7136599.
  • Brady-Nicholls R, Nagy JD, Gerke TA, Zhang T, Wang AZ, Zhang J, Gatenby RA, Enderling H. Prostate-specific antigen dynamics predict individual responses to intermittent androgen deprivation. Nat Commun. 2020 Apr.11(1):1750. Pubmedid: 32273504. Pmcid: PMC7145869.
  • Park DS, Robertson-Tessi M, Luddy KA, Maini PK, Bonsall MB, Gatenby RA, Anderson ARA. The Goldilocks Window of Personalized Chemotherapy: Getting the Immune Response Just Right. Cancer Res. 2019 Oct.79(20):5302-5315. Pubmedid: 31387920. Pmcid: PMC6801094.
  • El-Kenawi A, Gatenbee C, Robertson-Tessi M, Bravo R, Dhillon J, Balagurunathan Y, Berglund A, Visvakarma N, Ibrahim-Hashim A, Choi J, Luddy K, Gatenby R, Pilon-Thomas S, Anderson A, Ruffell B, Gillies R. Acidity promotes tumour progression by altering macrophage phenotype in prostate cancer. Brit J Cancer. 2019 Oct.121(7):556-566. Pubmedid: 31417189. Pmcid: PMC6889319.
  • Smalley I, Kim E, Li J, Spence P, Wyatt CJ, Eroglu Z, Sondak VK, Messina JL, Babacan NA, Maria-Engler SS, De Armas L, Williams SL, Gatenby RA, Chen YA, Anderson ARA, Smalley KSM. Leveraging transcriptional dynamics to improve BRAF inhibitor responses in melanoma. EBioMedicine. 2019 Oct.48:178-190. Pubmedid: 31594749. Pmcid: PMC6838387.
  • Frieden BR, Gatenby RA. Publisher Correction: Signal transmission through elements of the cytoskeleton form an optimized information network in eukaryotic cells. Sci Rep. 2019 Oct.9(1):14726. Pubmedid: 31591453. Pmcid: PMC6779750.
  • Howard R, Scheiner A, Cunningham J, Gatenby R. Cytoplasmic convection currents and intracellular temperature gradients. PLoS Comput Biol. 2019 Nov.15(11):e1007372. Pubmedid: 31682599. Pmcid: PMC6827888.
  • White FM, Gatenby RA, Fischbach C. The Physics of Cancer. Cancer Res. 2019 May.79(9):2107-2110. Pubmedid: 31018939. Pmcid: PMC6497564.
  • Stringfield O, Arrington JA, Johnston SK, Rognin NG, Peeri NC, Balagurunathan Y, Jackson PR, Clark-Swanson KR, Swanson KR, Egan KM, Gatenby RA, Raghunand N. Multiparameter MRI Predictors of Long-Term Survival in Glioblastoma Multiforme. Tomography. 2019 Mar.5(1):135-144. Pubmedid: 30854451. Pmcid: PMC6403044.
  • Rockne RC, Hawkins-Daarud A, Swanson KR, Sluka JP, Glazier JA, Macklin P, Hormuth D, Jarrett AM, Lima EABDF, Oden J, Biros G, Yankeelov TE, Curtius K, Bakir IA, Wodarz D, Komarova N, Aparicio L, Bordyuh M, Rabadan R, Finley S, Enderling H, Caudell JJ, Moros EG, Anderson ARA, Gatenby R, Kaznatcheev A, Jeavons P, Krishnan N, Pelesko J, Wadhwa RR, Yoon N, Nichol D, Marusyk A, Hinczewski M, Scott JG. The 2019 mathematical oncology roadmap. Phys Biol. 2019 Jun.16(4):041005. Pubmedid: 30991381. Pmcid: PMC6655440.
  • Gatenby R, Whelan C. Cancer treatment innovators discover Charles Darwin. Evol Med Public Health. 2019 Jun.2019(1):108-110. Pubmedid: 31304015. Pmcid: PMC6613535.
  • West JB, Dinh MN, Brown JS, Zhang J, Anderson AR, Gatenby RA. Multidrug Cancer Therapy in Metastatic Castrate-Resistant Prostate Cancer: An Evolution-Based Strategy. Clin Cancer Res. 2019 Jul.25(14):4413-4421. Pubmedid: 30992299. Pmcid: PMC6665681.
  • Gatenby RA, Zhang J, Brown JS. First Strike-Second Strike Strategies in Metastatic Cancer: Lessons from the Evolutionary Dynamics of Extinction. Cancer Res. 2019 Jul.79(13):3174-3177. Pubmedid: 31221821. Pmcid: PMC6606376.
  • Gatenby RA. The Role of Cell Membrane Information Reception, Processing, and Communication in the Structure and Function of Multicellular Tissue. Int J Mol Sci. 2019 Jul.20(15). Pubmedid: 31344783. Pmcid: PMC6696332.
  • Stanková K, Brown JS, Dalton WS, Gatenby RA. Optimizing Cancer Treatment Using Game Theory: A Review. JAMA Oncol. 2019 Jan.5(1):96-103. Pubmedid: 30098166. Pmcid: PMC6947530.
  • Frieden BR, Gatenby R. Ion-Based Cellular Signal Transmission, Principles of Minimum Information Loss, and Evolution by Natural Selection. Int J Mol Sci. 2019 Dec.21(1). Pubmedid: 31861371. Pmcid: PMC6982146.
  • Johnston SK, Whitmire P, Massey SC, Kumthekar P, Porter AB, Raghunand N, Gonzalez-Cuyar LF, Mrugala MM, Hawkins-Daarud A, Jackson PR, Hu LS, Sarkaria JN, Wang L, Gatenby RA, Egan KM, Canoll P, Swanson KR. ENvironmental Dynamics Underlying Responsive Extreme Survivors (ENDURES) of Glioblastoma: A Multidisciplinary Team-based, Multifactorial Analytical Approach. Am J Clin Oncol. 2019 Aug.42(8):655-661. Pubmedid: 31343422. Pmcid: PMC7416695.
  • Frieden BR, Gatenby RA. Signal transmission through elements of the cytoskeleton form an optimized information network in eukaryotic cells. Sci Rep. 2019 Apr.9(1):6110. Pubmedid: 30992457. Pmcid: PMC6467984.
  • Spring BQ, Lang RT, Kercher EM, Rizvi I, Wenham RM, Conejo-Garcia JR, Hasan T, Gatenby RA, Enderling H. Illuminating the Numbers: Integrating Mathematical Models to Optimize Photomedicine Dosimetry and Combination Therapies. Front Phys. 2019 Apr.7. Pubmedid: 31123672. Pmcid: PMC6529192.
  • Ujvari B, Jacqueline C, Misse D, Amar V, Fitzpatrick JC, Jennings G, Beckmann C, Rome S, Biro PA, Gatenby R, Brown J, Almeida L, Thomas F. Obesity paradox in cancer: Is bigger really better?. Evol Appl. 2019 Apr.12(6):1092-1095. Pubmedid: 31293625. Pmcid: PMC6597865.
  • Gillies RJ, Brown JS, Anderson ARA, Gatenby RA. Eco-evolutionary causes and consequences of temporal changes in intratumoural blood flow. Nat Rev Cancer. 2018 Sep.18(9):576-585. Pubmedid: 29891961. Pmcid: PMC6441333.
  • Thomas F, Donnadieu E, Charriere GM, Jacqueline C, Tasiemski A, Pujol P, Renaud F, Roche B, Hamede R, Brown J, Gatenby R, Ujvari B. Is adaptive therapy natural?. PLoS Biol. 2018 Oct.16(10):e2007066. Pubmedid: 30278037. Pmcid: PMC6168119.
  • Gravenmier CA, Siddique M, Gatenby RA. Adaptation to Stochastic Temporal Variations in Intratumoral Blood Flow: The Warburg Effect as a Bet Hedging Strategy. Bull Math Biol. 2018 May.80(5):954-970. Pubmedid: 28508297. Pmcid: PMC5685950.
  • Gatenby R, Brown J. The Evolution and Ecology of Resistance in Cancer Therapy. Cold Spring Harb Perspect Med. 2018 Mar.8(3). Pubmedid: 28710258. Pmcid: PMC5830903.
  • Subramanian H, Gatenby RA. Evolutionary advantage of directional symmetry breaking in self-replicating polymers. J Theor Biol. 2018 Jun.446:128-136. Pubmedid: 29544886. Pmcid: PMC5891365.
  • Subramanian H, Gatenby RA. Chiral Monomers Ensure Orientational Specificity of Monomer Binding During Polymer Self-Replication. J Mol Evol. 2018 Jun.86(5):255-263. Pubmedid: 29725703.
  • McGettigan MJ, Gatenby RA. Radiologic Pearls for Internists: A Case-Based Review. Am J Med. 2018 Jan.131(1):9-16. Pubmedid: 28889930.
  • Zhou M, Scott J, Chaudhury B, Hall L, Goldgof D, Yeom KW, Iv M, Ou Y, Kalpathy-Cramer J, Napel S, Gillies R, Gevaert O, Gatenby R. Radiomics in Brain Tumor: Image Assessment, Quantitative Feature Descriptors, and Machine-Learning Approaches. Ajnr Am J Neuroradiol. 2018 Feb.39(2):208-216. Pubmedid: 28982791. Pmcid: PMC5812810.
  • Cunningham JJ, Brown JS, Gatenby RA, Staňková K. Optimal control to develop therapeutic strategies for metastatic castrate resistant prostate cancer. J Theor Biol. 2018 Dec.459:67-78. Pubmedid: 30243754.
  • Gallaher J, Enriquez-Navas PM, Luddy KA, Gatenby RA, Anderson AR. Spatial Heterogeneity and Evolutionary Dynamics Modulate Time to Recurrence in Continuous and Adaptive Cancer Therapies. Cancer Res. 2018 Apr.78(8):2127-2139. Pubmedid: 29382708. Pmcid: PMC5899666.
  • Epstein T, Gatenby RA, Brown JS. The Warburg effect as an adaptation of cancer cells to rapid fluctuations in energy demand. PLoS One. 2017 Sep.12(9):e0185085. Pubmedid: 28922380. Pmcid: PMC5602667.
  • Maley CC, Aktipis A, Graham TA, Sottoriva A, Boddy AM, Janiszewska M, Silva AS, Gerlinger M, Yuan Y, Pienta KJ, Anderson KS, Gatenby R, Swanton C, Posada D, Wu CI, Schiffman JD, Hwang ES, Polyak K, Anderson ARA, Brown JS, Greaves M, Shibata D. Classifying the evolutionary and ecological features of neoplasms. Nat Rev Cancer. 2017 Oct.17(10):605-619. Pubmedid: 28912577. Pmcid: PMC5811185.
  • Gatenby RA, Frieden BR. Cellular information dynamics through transmembrane flow of ions. Sci Rep. 2017 Nov.7(1):15075. Pubmedid: 29118414. Pmcid: PMC5678125.
  • Zhang J, Cunningham JJ, Brown JS, Gatenby RA. Integrating evolutionary dynamics into treatment of metastatic castrate-resistant prostate cancer. Nat Commun. 2017 Nov.8(1):1816. Pubmedid: 29180633. Pmcid: PMC5703947.
  • Ibrahim-Hashim A, Robertson-Tessi M, Enrizues-Navas P, Damaghi M, Balagurunathan Y, Wojtkowiak JW, Russell S, Yoonseok K, Lloyd MC, Bui MM, Brown JS, Anderson AR, Gillies RJ, Gatenby RA. Defining Cancer Subpopulations by Adaptive Strategies Rather Than Molecular Properties Provides Novel Insights into Intratumoral Evolution. Cancer Res. 2017 May.77(9):2242-2254. Pubmedid: 28249898. Pmcid: PMC6005351.
  • Brown J, Cunningham JJ, Gatenby RA. Aggregation Effects and Population-Based Dynamics as a Source of Therapy Resistance in Cancer. IEEE Trans Biomed Eng. 2017 Mar.64(3):512-518. Pubmedid: 28113286. Pmcid: PMC5438296.
  • Picco N, Gatenby RA, Anderson AR. Stem Cell Plasticity and Niche Dynamics in Cancer Progression. IEEE Trans Biomed Eng. 2017 Mar.64(3):528-537. Pubmedid: 28113244. Pmcid: PMC5634531.
  • Silva AS, Silva MC, Sudalagunta P, Distler AI, Jacobson T, Collins A, Nguyen T, Song J, Chen DT, Chen L, Cubitt CL, Baz R, Perez L, Rebatchouk D, Dalton W, Greene J, Gatenby RA, Gillies RJ, Sontag E, Meads MB, Shain K. An Ex Vivo Platform for the Prediction of Clinical Response in Multiple Myeloma. Cancer Res. 2017 Jun.77(12):3336-3351. Pubmedid: 28400475. Pmcid: PMC7819642.
  • Zhou M, Chaudhury B, Hall LO, Goldgof DB, Gillies RJ, Gatenby RA. Identifying spatial imaging biomarkers of glioblastoma multiforme for survival group prediction. J Magn Reson Imaging. 2017 Jul.46(1):115-123. Pubmedid: 27678245.
  • Ibrahim-Hashim A, Abrahams D, Enriquez-Navas PM, Luddy K, Gatenby RA, Gillies RJ. Tris-base buffer: a promising new inhibitor for cancer progression and metastasis. Cancer Med. 2017 Jul.6(7):1720-1729. Pubmedid: 28556628. Pmcid: PMC5504318.
  • Gatenby RA. Is the Genetic Paradigm of Cancer Complete?. Radiology. 2017 Jul.284(1):1-3. Pubmedid: 28628406.
  • Kim JY, Gatenby RA. Quantitative Clinical Imaging Methods for Monitoring Intratumoral Evolution. Methods Mol Biol. 2017 Dec.1513:61-81. Pubmedid: 27807831.
  • You L, Brown JS, Thuijsman F, Cunningham JJ, Gatenby RA, Zhang J, Staňková K. Spatial vs. non-spatial eco-evolutionary dynamics in a tumor growth model. J Theor Biol. 2017 Dec.435:78-97. Pubmedid: 28870617.
  • Gatenby RA, Brown J. Mutations, evolution and the central role of a self-defined fitness function in the initiation and progression of cancer. BBA. Reviews on cancer. 2017 Apr.1867(2):162-166. Pubmedid: 28341421. Pmcid: PMC5441954.
  • Gatenby R. Cancer biology and Mr. Darwin. BBA. Reviews on cancer. 2017 Apr.1867(2):67-68. Pubmedid: 28412279.
  • Arrington JA, Klippenstein DL, Gatenby RA. Innovations in Diagnostic Imaging and the Transformation of the Clinical Practice of Radiology in Collaborative, Multidisciplinary Cancer Care. Cancer Control. 2017 Apr.24(2):115-117. Pubmedid: 28441378.
  • Picco N, Gatenby RA, Anderson AR. Stem Cell Plasticity And Niche Dynamics in Cancer Progression. IEEE Trans Biomed Eng. 2016 Sep. Pubmedid: 27623570.
  • Cheemalapati SV, Winskas J, Wang H, Konnaiyan K, Zhdanov A, Roth A, Adapa SR, Deonarine A, Noble M, Das T, Gatenby R, Westerheide SD, Jiang RH, Pyayt A. Subcellular and in-vivo Nano-Endoscopy. Sci Rep. 2016 Oct.6:34400. Pubmedid: 27694854. Pmcid: PMC5046067.
  • Brown J, Cunningham JJ, Gatenby RA. Aggregation Effects and Population-based dynamics as a source of therapy resistance in cancer. IEEE Trans Biomed Eng. 2016 Nov. Pubmedid: 27831855.
  • Gatenby R, Frieden BR. Investigating Information Dynamics in Living Systems through the Structure and Function of Enzymes. PLoS One. 2016 May.11(5):e0154867. Pubmedid: 27149068. Pmcid: PMC4857929.
  • Lloyd MC, Cunningham JJ, Bui MM, Gillies RJ, Brown JS, Gatenby RA. Darwinian Dynamics of Intratumoral Heterogeneity: Not Solely Random Mutations but Also Variable Environmental Selection Forces. Cancer Res. 2016 Jun.76(11):3136-3144. Pubmedid: 27009166. Pmcid: PMC5384728.
  • Ujvari B, Gatenby RA, Thomas F. Transmissible cancers, are they more common than thought?. Evol Appl. 2016 Jun.9(5):633-634. Pubmedid: 27398093. Pmcid: PMC4869404.
  • Enriquez-Navas PM, Kam Y, Das T, Hassan S, Silva A, Foroutan P, Ruiz E, Martinez G, Minton S, Gillies RJ, Gatenby RA. Exploiting evolutionary principles to prolong tumor control in preclinical models of breast cancer. Sci Transl Med. 2016 Feb.8(327):327ra24. Pubmedid: 26912903. Pmcid: PMC4962860.
  • Hawkins S, Wang H, Liu Y, Garcia A, Stringfield O, Krewer H, Li Q, Cherezov D, Gatenby RA, Balagurunathan Y, Goldgof D, Schabath MB, Hall L, Gillies RJ. Predicting Malignant Nodules from Screening CT Scans. J Thorac Oncol. 2016 Dec.11(12):2120-2128. Pubmedid: 27422797. Pmcid: PMC5545995.
  • Thomas F, Nesse RM, Gatenby R, Gidoin C, Renaud F, Roche B, Ujvari B. Evolutionary Ecology of Organs: A Missing Link in Cancer Development?. Trends Cancer. 2016 Aug.2(8):409-415. Pubmedid: 28741494.
  • Ujvari B, Gatenby RA, Thomas F. The evolutionary ecology of transmissible cancers. Infect Genet Evol. 2016 Apr.39:293-303. Pubmedid: 26861618.
  • Nichol D, Jeavons P, Fletcher AG, Bonomo RA, Maini PK, Paul JL, Gatenby RA, Anderson AR, Scott JG. Steering Evolution with Sequential Therapy to Prevent the Emergence of Bacterial Antibiotic Resistance. PLoS Comput Biol. 2015 Sep.11(9):e1004493. Pubmedid: 26360300. Pmcid: PMC4567305.
  • Chaudhury B, Zhou M, Goldgof DB, Hall LO, Gatenby RA, Gillies RJ, Patel BK, Weinfurtner RJ, Drukteinis JS. Heterogeneity in intratumoral regions with rapid gadolinium washout correlates with estrogen receptor status and nodal metastasis. J Magn Reson Imaging. 2015 Nov.42(5):1421-1430. Pubmedid: 25884277. Pmcid: PMC5017794.
  • Enriquez-Navas PM, Wojtkowiak JW, Gatenby RA. Application of Evolutionary Principles to Cancer Therapy. Cancer Res. 2015 Nov.75(22):4675-4680. Pubmedid: 26527288. Pmcid: PMC4693617.
  • Fais S, Venturi G, Gatenby RA. Erratum to: microenvironmental acidosis in carcinogenesis and metastases: new strategies in prevention and therapy. Cancer Metastasis Rev. 2015 Mar.34(1):165. Pubmedid: 25430903. Pmcid: PMC4643551.
  • Grove O, Berglund AE, Schabath MB, Aerts HJ, Dekker A, Wang H, Velazquez ER, Lambin P, Gu Y, Balagurunathan Y, Eikman E, Gatenby RA, Eschrich S, Gillies RJ. Quantitative computed tomographic descriptors associate tumor shape complexity and intratumor heterogeneity with prognosis in lung adenocarcinoma. PLoS One. 2015 Mar.10(3):e0118261. Pubmedid: 25739030. Pmcid: PMC4349806.
  • Cunningham JJ, Brown JS, Vincent TL, Gatenby RA. Divergent and convergent evolution in metastases suggest treatment strategies based on specific metastatic sites. Evol Med Public Health. 2015 Mar.2015(1):76-87. Pubmedid: 25794501. Pmcid: PMC4404930.
  • Verduzco D, Lloyd M, Xu L, Ibrahim-Hashim A, Balagurunathan Y, Gatenby RA, Gillies RJ. Intermittent hypoxia selects for genotypes and phenotypes that increase survival, invasion, and therapy resistance. PLoS One. 2015 Mar.10(3):e0120958. Pubmedid: 25811878. Pmcid: PMC4374837.
  • Gillies RJ, Gatenby RA. Metabolism and its sequelae in cancer evolution and therapy. Cancer J. 2015 Mar.21(2):88-96. Pubmedid: 25815848. Pmcid: PMC4446699.
  • Lloyd MC, Rejniak KA, Brown JS, Gatenby RA, Minor ES, Bui MM. Pathology to enhance precision medicine in oncology: lessons from landscape ecology. Adv Anat Pathol. 2015 Jul.22(4):267-272. Pubmedid: 26050264. Pmcid: PMC4729443.
  • Brown JS, Cunningham JJ, Gatenby RA. The multiple facets of Peto's paradox: a life-history model for the evolution of cancer suppression. Philos Trans R Soc Lond B Biol Sci. 2015 Jul.370(1673). Pubmedid: 26056365. Pmcid: PMC4581026.
  • Arnal A, Ujvari B, Crespi B, Gatenby RA, Tissot T, Vittecoq M, Ewald PW, Casali A, Ducasse H, Jacqueline C, Missé D, Renaud F, Roche B, Thomas F. Evolutionary perspective of cancer: myth, metaphors, and reality. Evol Appl. 2015 Jul.8(6):541-544. Pubmedid: 26136820. Pmcid: PMC4479510.
  • Ducasse H, Arnal A, Vittecoq M, Daoust SP, Ujvari B, Jacqueline C, Tissot T, Ewald P, Gatenby RA, King KC, Bonhomme F, Brodeur J, Renaud F, Solary E, Roche B, Thomas F. Cancer: an emergent property of disturbed resource-rich environments? Ecology meets personalized medicine. Evol Appl. 2015 Jul.8(6):527-540. Pubmedid: 26136819. Pmcid: PMC4479509.
  • Shiraishi T, Verdone JE, Huang J, Kahlert UD, Hernandez JR, Torga G, Zarif JC, Epstein T, Gatenby R, McCartney A, Elisseeff JH, Mooney SM, An SS, Pienta KJ. Glycolysis is the primary bioenergetic pathway for cell motility and cytoskeletal remodeling in human prostate and breast cancer cells. Oncotarget. 2015 Jan.6(1):130-143. Pubmedid: 25426557. Pmcid: PMC4381583.
  • Frieden BR, Gatenby RA. Cancer suppression by compression. Bull Math Biol. 2015 Jan.77(1):71-82. Pubmedid: 25520262.
  • Wojtkowiak JW, Cornnell HC, Matsumoto S, Saito K, Takakusagi Y, Dutta P, Kim M, Zhang X, Leos R, Bailey KM, Martinez G, Lloyd MC, Weber C, Mitchell JB, Lynch RM, Baker AF, Gatenby RA, Rejniak KA, Hart C, Krishna MC, Gillies RJ. Pyruvate sensitizes pancreatic tumors to hypoxia-activated prodrug TH-302. Cancer Metab. 2015 Jan.3(1):2. Pubmedid: 25635223. Pmcid: PMC4310189.
  • Jansen G, Gatenby R, Aktipis CA. Opinion: Control vs. eradication: applying infectious disease treatment strategies to cancer. Proc Natl Acad Sci U S A. 2015 Jan.112(4):937-938. Pubmedid: 25628412. Pmcid: PMC4313808.
  • Kam Y, Das T, Tian H, Foroutan P, Ruiz E, Martinez G, Minton S, Gillies RJ, Gatenby RA. Sweat but no gain: inhibiting proliferation of multidrug resistant cancer cells with "ersatzdroges". Int J Cancer. 2015 Feb.136(4):E188-E196. Pubmedid: 25156304. Pmcid: PMC4262548.
  • Damaghi M, Tafreshi NK, Lloyd MC, Sprung R, Estrella V, Wojtkowiak JW, Morse DL, Koomen JM, Bui MM, Gatenby RA, Gillies RJ. Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane. Nat Commun. 2015 Dec.6:8752. Pubmedid: 26658462. Pmcid: PMC4682176.
  • Wu A, Zhang Q, Lambert G, Khin Z, Gatenby RA, Kim HJ, Pourmand N, Bussey K, Davies PC, Sturm JC, Austin RH. Ancient hot and cold genes and chemotherapy resistance emergence. Proc Natl Acad Sci U S A. 2015 Aug.112(33):10467-10472. Pubmedid: 26240372. Pmcid: PMC4547268.
  • Robertson-Tessi M, Gillies RJ, Gatenby RA, Anderson AR. Impact of metabolic heterogeneity on tumor growth, invasion, and treatment outcomes. Cancer Res. 2015 Apr.75(8):1567-1579. Pubmedid: 25878146. Pmcid: PMC4421891.
  • Colen R, Foster I, Gatenby R, Giger ME, Gillies R, Gutman D, Heller M, Jain R, Madabhushi A, Madhavan S, Napel S, Rao A, Saltz J, Tatum J, Verhaak R, Whitman G. NCI Workshop Report: Clinical and Computational Requirements for Correlating Imaging Phenotypes with Genomics Signatures. Transl Oncol. 2014 Oct.7(5):556-569. Pubmedid: 25389451. Pmcid: PMC4225695.
  • Gatenby RA, Cunningham JJ, Brown JS. Evolutionary triage governs fitness in driver and passenger mutations and suggests targeting never mutations. Nat Commun. 2014 Nov.5:5499. Pubmedid: 25407411. Pmcid: PMC4260773.
  • Epstein T, Xu L, Gillies RJ, Gatenby RA. Separation of metabolic supply and demand: aerobic glycolysis as a normal physiological response to fluctuating energetic demands in the membrane. Cancer Metab. 2014 Jun.2:7. Pubmedid: 24982758. Pmcid: PMC4060846.
  • Kam Y, Das T, Minton S, Gatenby RA. Evolutionary strategy for systemic therapy of metastatic breast cancer: balancing response with suppression of resistance. Womens Health (Lond Engl). 2014 Jul.10(4):423-430. Pubmedid: 25259902. Pmcid: PMC4258899.
  • Balagurunathan Y, Gu Y, Wang H, Kumar V, Grove O, Hawkins S, Kim J, Goldgof DB, Hall LO, Gatenby RA, Gillies RJ. Reproducibility and Prognosis of Quantitative Features Extracted from CT Images. Transl Oncol. 2014 Feb.7(1):72-87. Pubmedid: 24772210. Pmcid: PMC3998690.
  • Zhou M, Hall L, Goldgof D, Russo R, Balagurunathan Y, Gillies R, Gatenby R. Radiologically defined ecological dynamics and clinical outcomes in glioblastoma multiforme: preliminary results. Transl Oncol. 2014 Feb.7(1):5-13. Pubmedid: 24772202. Pmcid: PMC3998688.
  • Balagurunathan Y, Kumar V, Gu Y, Kim J, Wang H, Liu Y, Goldgof DB, Hall LO, Korn R, Zhao B, Schwartz LH, Basu S, Eschrich S, Gatenby RA, Gillies RJ. Test-retest reproducibility analysis of lung CT image features. J Digit Imaging. 2014 Dec.27(6):805-823. Pubmedid: 24990346. Pmcid: PMC4391075.
  • Lloyd MC, Alfarouk KO, Verduzco D, Bui MM, Gillies RJ, Ibrahim ME, Brown JS, Gatenby RA. Vascular measurements correlate with estrogen receptor status. BMC Cancer. 2014 Apr.14:279. Pubmedid: 24755315. Pmcid: PMC4012762.
  • Rose T, Caracciolo J, Gatenby R. Cancer survivorship, a unique and growing cohort in medical practice: radiology perspective. Am J Med. 2013 Sep.126(9):759-767. Pubmedid: 23870789.
  • Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PC, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C, Foo J, Fraley SI, Frantz C, Fuhrmann A, Gascard P, Gatenby RA, Geng Y, Gerecht S, Gillies RJ, Godin B, Grady WM, Greenfield A, Hemphill C, Hempstead BL, Hielscher A, Hillis WD, Holland EC, Ibrahim-Hashim A, Jacks T, Johnson RH, Joo A, Katz JE, Kelbauskas L, Kesselman C, King MR, Konstantopoulos K, Kraning-Rush CM, Kuhn P, Kung K, Kwee B, Lakins JN, Lambert G, Liao D, Licht JD, Liphardt JT, Liu L, Lloyd MC, Lyubimova A, Mallick P, Marko J, McCarty OJ, Meldrum DR, Michor F, Mumenthaler SM, Nandakumar V, O'Halloran TV, Oh S, Pasqualini R, Paszek MJ, Philips KG, Poultney CS, Rana K, Reinhart-King CA, Ros R, Semenza GL, Senechal P, Shuler ML, Srinivasan S, Staunton JR, Stypula Y, Subramanian H, Tlsty TD, Tormoen GW, Tseng Y, van Oudenaarden A, Verbridge SS, Wan JC, Weaver VM, Widom J, Will C, Wirtz D, Wojtkowiak J, Wu PH. A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep. 2013 Oct.3:1449. Pubmedid: 23618955. Pmcid: PMC3636513.
  • Gatenby RA, Grove O, Gillies RJ. Quantitative imaging in cancer evolution and ecology. Radiology. 2013 Oct.269(1):8-15. Pubmedid: 24062559. Pmcid: PMC3781355.
  • Frieden BR, Gatenby RA. Principle of maximum Fisher information from Hardy's axioms applied to statistical systems. Phys Rev E Stat Nonlin Soft Matter Phys. 2013 Oct.88(4):042144. Pubmedid: 24229152. Pmcid: PMC4010149.
  • Estrella V, Chen T, Lloyd M, Wojtkowiak J, Cornnell HH, Ibrahim-Hashim A, Bailey K, Balagurunathan Y, Rothberg JM, Sloane BF, Johnson J, Gatenby RA, Gillies RJ. Acidity generated by the tumor microenvironment drives local invasion. Cancer Res. 2013 Mar.73(5):1524-1535. Pubmedid: 23288510. Pmcid: PMC3594450.
  • Kumar V, Nath K, Berman CG, Kim J, Tanvetyanon T, Chiappori AA, Gatenby RA, Gillies RJ, Eikman EA. Variance of SUVs for FDG-PET/CT is greater in clinical practice than under ideal study settings. Clin Nucl Med. 2013 Mar.38(3):175-182. Pubmedid: 23354032. Pmcid: PMC3578161.
  • Gu Y, Kumar V, Hall LO, Goldgof DB, Li CY, Korn R, Bendtsen C, Velazquez ER, Dekker A, Aerts H, Lambin P, Li X, Tian J, Gatenby RA, Gillies RJ. Automated Delineation of Lung Tumors from CT Images Using a Single Click Ensemble Segmentation Approach. Pattern Recognit. 2013 Mar.46(3):692-702. Pubmedid: 23459617. Pmcid: PMC3580869.
  • Orlando PA, Gatenby RA, Brown JS. Tumor evolution in space: the effects of competition colonization tradeoffs on tumor invasion dynamics. Front Oncol. 2013 Mar.3:45. Pubmedid: 23508890. Pmcid: PMC3589695.
  • Drukteinis JS, Mooney BP, Flowers CI, Gatenby RA. Beyond mammography: new frontiers in breast cancer screening. Am J Med. 2013 Jun.126(6):472-479. Pubmedid: 23561631. Pmcid: PMC4010151.
  • Rietman EA, Friesen DE, Hahnfeldt P, Gatenby R, Hlatky L, Tuszynski JA. An integrated multidisciplinary model describing initiation of cancer and the Warburg hypothesis. Theor Biol Med Model. 2013 Jun.10:39. Pubmedid: 23758735. Pmcid: PMC3689044.
  • Liu L, Duclos G, Sun B, Lee J, Wu A, Kam Y, Sontag ED, Stone HA, Sturm JC, Gatenby RA, Austin RH. Minimization of thermodynamic costs in cancer cell invasion. Proc Natl Acad Sci U S A. 2013 Jan.110(5):1686-1691. Pubmedid: 23319630. Pmcid: PMC3562811.
  • Alfarouk KO, Ibrahim ME, Gatenby RA, Brown JS. Riparian ecosystems in human cancers. Evol Appl. 2013 Jan.6(1):46-53. Pubmedid: 23396634. Pmcid: PMC3567470.
  • Aktipis CA, Boddy AM, Gatenby RA, Brown JS, Maley CC. Life history trade-offs in cancer evolution. Nat Rev Cancer. 2013 Dec.13(12):883-892. Pubmedid: 24213474. Pmcid: PMC4010142.
  • Gatenby RA. Commentary on a paper by Verbeni et al. Phys Life Rev. 2013 Dec.10(4):480-481. Pubmedid: 24231516.
  • Orlando PA, Brown JS, Gatenby RA, Giuliano AR. The ecology of human papillomavirus-induced epithelial lesions and the role of somatic evolution in their progression. J Infect Dis. 2013 Aug.208(3):394-402. Pubmedid: 23599315. Pmcid: PMC3698999.
  • Gatenby RA, Frieden BR. The critical roles of information and nonequilibrium thermodynamics in evolution of living systems. Bull Math Biol. 2013 Apr.75(4):589-601. Pubmedid: 23456476. Pmcid: PMC4073208.
  • Cunningham J, Estrella V, Lloyd M, Gillies R, Frieden BR, Gatenby R. Intracellular electric field and pH optimize protein localization and movement. PLoS One. 2012 Sep.7(5):e36894. Pubmedid: 22623963. Pmcid: PMC3356409.
  • Roche B, Hochberg ME, Caulin AF, Maley CC, Gatenby RA, Misse D, Thomas F. Natural resistance to cancers: a Darwinian hypothesis to explain Peto's paradox. BMC Cancer. 2012 Sep.12:387. Pubmedid: 22943484. Pmcid: PMC3488527.
  • Gillies RJ, Flowers CI, Drukteinis JS, Gatenby RA. A unifying theory of carcinogenesis, and why targeted therapy doesn't work. Eur J Radiol. 2012 Sep.81 Suppl 1:S48-S50. Pubmedid: 23083599.
  • Kumar V, Gu Y, Basu S, Berglund A, Eschrich SA, Schabath MB, Forster K, Aerts HJ, Dekker A, Fenstermacher D, Goldgof DB, Hall LO, Lambin P, Balagurunathan Y, Gatenby RA, Gillies RJ. Radiomics: the process and the challenges. Magn Reson Imaging. 2012 Nov.30(9):1234-1248. Pubmedid: 22898692. Pmcid: PMC3563280.
  • Gatenby R. Perspective: Finding cancer's first principles. Nature. 2012 Nov.491(7425):S55. Pubmedid: 23320287.
  • Martin NK, Robey IF, Gaffney EA, Gillies RJ, Gatenby RA, Maini PK. Predicting the safety and efficacy of buffer therapy to raise tumour pHe: an integrative modelling study. Brit J Cancer. 2012 Mar.106(7):1280-1287. Pubmedid: 22382688. Pmcid: PMC3314784.
  • Gillies RJ, Verduzco D, Gatenby RA. Evolutionary dynamics of carcinogenesis and why targeted therapy does not work. Nat Rev Cancer. 2012 Jun.12(7):487-493. Pubmedid: 22695393. Pmcid: PMC4122506.
  • Orlando PA, Gatenby RA, Giuliano AR, Brown JS. Evolutionary ecology of human papillomavirus: trade-offs, coexistence, and origins of high-risk and low-risk types. J Infect Dis. 2012 Jan.205(2):272-279. Pubmedid: 22090448. Pmcid: PMC3244363.
  • Silva AS, Kam Y, Khin ZP, Minton SE, Gillies RJ, Gatenby RA. Evolutionary approaches to prolong progression-free survival in breast cancer. Cancer Res. 2012 Dec.72(24):6362-6370. Pubmedid: 23066036. Pmcid: PMC3525750.
  • Orlando PA, Gatenby RA, Brown JS. Cancer treatment as a game: integrating evolutionary game theory into the optimal control of chemotherapy. Phys Biol. 2012 Dec.9(6):065007. Pubmedid: 23197192. Pmcid: PMC3653600.
  • Ibrahim-Hashim A, Cornnell HH, Abrahams D, Lloyd M, Bui M, Gillies RJ, Gatenby RA. Systemic buffers inhibit carcinogenesis in TRAMP mice. J Urol. 2012 Aug.188(2):624-631. Pubmedid: 22704445. Pmcid: PMC3694604.
  • Ribeiro MdLC, Silva AS, Bailey KM, Kumar NB, Sellers TA, Gatenby RA, Arig IH, Gillies RJ. Buffer Therapy for Cancer. J Nutr Food Sci. 2012 Aug.2:6. Pubmedid: 24371544. Pmcid: PMC3872072.
  • Basanta D, Gatenby RA, Anderson AR. Exploiting evolution to treat drug resistance: combination therapy and the double bind. Mol Pharm. 2012 Apr.9(4):914-921. Pubmedid: 22369188. Pmcid: PMC3325107.
  • Lee HO, Silva AS, Concilio S, Li YS, Slifker M, Gatenby RA, Cheng JD. Evolution of tumor invasiveness: the adaptive tumor microenvironment landscape model. Cancer Res. 2011 Oct.71(20):6327-6337. Pubmedid: 21859828. Pmcid: PMC3197231.
  • Ibrahim-Hashim A, Wojtkowiak JW, de Lourdes Coelho Ribeiro M, Estrella V, Bailey KM, Cornnell HH, Gatenby RA, Gillies RJ. Free Base Lysine Increases Survival and Reduces Metastasis in Prostate Cancer Model. J Cancer Sci Ther. 2011 Nov.Suppl 1(4). Pubmedid: 24032073. Pmcid: PMC3768133.
  • Martin NK, Gaffney EA, Gatenby RA, Gillies RJ, Robey IF, Maini PK. A mathematical model of tumour and blood pHe regulation: The HCO3-/CO2 buffering system. Math Biosci. 2011 Mar.230(1):1-11. Pubmedid: 21167185. Pmcid: PMC3045481.
  • Basu S, Kwee TC, Gatenby R, Saboury B, Torigian DA, Alavi A. Evolving role of molecular imaging with PET in detecting and characterizing heterogeneity of cancer tissue at the primary and metastatic sites, a plausible explanation for failed attempts to cure malignant disorders. Eur J Nucl Med Mol Imaging. 2011 Jun.38(6):987-991. Pubmedid: 21451997.
  • Cunningham JJ, Gatenby RA, Brown JS. Evolutionary dynamics in cancer therapy. Mol Pharm. 2011 Dec.8(6):2094-2100. Pubmedid: 21815657. Pmcid: PMC3250072.
  • Frieden BR, Gatenby RA. Information dynamics in living systems: prokaryotes, eukaryotes, and cancer. PLoS One. 2011 Dec.6(7):e22085. Pubmedid: 21818295. Pmcid: PMC3139603.
  • Ibrahim Hashim A, Cornnell HH, Coelho Ribeiro Mde L, Abrahams D, Cunningham J, Lloyd M, Martinez GV, Gatenby RA, Gillies RJ. Reduction of metastasis using a non-volatile buffer. Clin Exp Metastas. 2011 Dec.28(8):841-849. Pubmedid: 21861189. Pmcid: PMC3213349.
  • Silva AS, Gatenby RA. Adaptation to survival in germinal center is the initial step in onset of indolent stage of multiple myeloma. Mol Pharm. 2011 Dec.8(6):2012-2020. Pubmedid: 21958215. Pmcid: PMC3437606.
  • Gatenby RA, Gillies RJ. Integrated imaging of cancer metabolism. Acad Radiol. 2011 Aug.18(8):929-931. Pubmedid: 21718952. Pmcid: PMC3753802.
  • Schofield JW, Gaffney EA, Gatenby RA, Maini PK. Tumour angiogenesis: the gap between theory and experiments. J Theor Biol. 2011 Apr.274(1):97-102. Pubmedid: 21255588. Pmcid: PMC4010154.
  • Perfahl H, Byrne HM, Chen T, Estrella V, Alarcón T, Lapin A, Gatenby RA, Gillies RJ, Lloyd MC, Maini PK, Reuss M, Owen MR. Multiscale modelling of vascular tumour growth in 3D: the roles of domain size and boundary conditions. PLoS One. 2011 Apr.6(4):e14790. Pubmedid: 21533234. Pmcid: PMC3076378.
  • Gatenby RA, Gillies RJ, Brown JS. Of cancer and cave fish. Nat Rev Cancer. 2011 Apr.11(4):237-238. Pubmedid: 21548400. Pmcid: PMC3971416.
  • Silva A, Anderson AR, Gatenby R. A multiscale model of the bone marrow and hematopoiesis. Math Biosci Eng. 2011 Apr.8(2):643-658. Pubmedid: 21631151. Pmcid: PMC3754791.
  • Huber V, De Milito A, Harguindey S, Reshkin SJ, Wahl ML, Rauch C, Chiesi A, Pouyssegur J, Gatenby RA, Rivoltini L, Fais S. Proton dynamics in cancer. J Transl Med. 2010 Jun.8:57. Pubmedid: 20550689. Pmcid: PMC2905351.
  • Gillies RJ, Anderson AR, Gatenby RA, Morse DL. The biology underlying molecular imaging in oncology: from genome to anatome and back again. Clin Radiol. 2010 Jul.65(7):517-521. Pubmedid: 20541651. Pmcid: PMC4009364.
  • Tafreshi NK, Kumar V, Morse DL, Gatenby RA. Molecular and functional imaging of breast cancer. Cancer Control. 2010 Jul.17(3):143-155. Pubmedid: 20664511.
  • Wolkenhauer O, Auffray C, Baltrusch S, Blüthgen N, Byrne H, Cascante M, Ciliberto A, Dale T, Drasdo D, Fell D, Ferrell JE, Gallahan D, Gatenby R, Günther U, Harms BD, Herzel H, Junghanss C, Kunz M, van Leeuwen I, Lenormand P, Levi F, Linnebacher M, Lowengrub J, Maini PK, Malik A, Rateitschak K, Sansom O, Schäfer R, Schürrle K, Sers C, Schnell S, Shibata D, Tyson J, Vera J, White M, Zhivotovsky B, Jaster R. Systems biologists seek fuller integration of systems biology approaches in new cancer research programs. Cancer Res. 2010 Jan.70(1):12-13. Pubmedid: 20028868. Pmcid: PMC2802734.
  • Silva AS, Gatenby RA, Gillies RJ, Yunes JA. A quantitative theoretical model for the development of malignancy in ductal carcinoma in situ. J Theor Biol. 2010 Feb.262(4):601-613. Pubmedid: 19887072.
  • Martin NK, Gaffney EA, Gatenby RA, Maini PK. Leaky vessels as a potential source of stromal acidification in tumours. J Theor Biol. 2010 Dec.267(3):454-460. Pubmedid: 20699102. Pmcid: PMC2963718.
  • Martin NK, Gaffney EA, Gatenby RA, Maini PK. Tumour-stromal interactions in acid-mediated invasion: a mathematical model. J Theor Biol. 2010 Dec.267(3):461-470. Pubmedid: 20816684. Pmcid: PMC3005191.
  • Gatenby RA, Frieden BR. Coulomb interactions between cytoplasmic electric fields and phosphorylated messenger proteins optimize information flow in cells. PLoS One. 2010 Aug.5(8):e12084. Pubmedid: 20711447. Pmcid: PMC2920310.
  • Smallbone K, Maini PK, Gatenby RA. Episodic, transient systemic acidosis delays evolution of the malignant phenotype: Possible mechanism for cancer prevention by increased physical activity. Biol Direct. 2010 Apr.5:22. Pubmedid: 20406440. Pmcid: PMC2864239.
  • Silva AS, Gatenby RA. A theoretical quantitative model for evolution of cancer chemotherapy resistance. Biol Direct. 2010 Apr.5:25. Pubmedid: 20406443. Pmcid: PMC2868834.
  • Meads MB, Gatenby RA, Dalton WS. Environment-mediated drug resistance: a major contributor to minimal residual disease. Nat Rev Cancer. 2009 Sep.9(9):665-674. Pubmedid: 19693095.
  • Gatenby RA, Brown J, Vincent T. Lessons from applied ecology: cancer control using an evolutionary double bind. Cancer Res. 2009 Oct.69(19):7499-7502. Pubmedid: 19752088.
  • Frieboes HB, Edgerton ME, Fruehauf JP, Rose FR, Worrall LK, Gatenby RA, Ferrari M, Cristini V. Prediction of drug response in breast cancer using integrative experimental/computational modeling. Cancer Res. 2009 May.69(10):4484-4492. Pubmedid: 19366802. Pmcid: PMC2720602.
  • Gatenby RA. A change of strategy in the war on cancer. Nature. 2009 May.459(7246):508-509. Pubmedid: 19478766.
  • Silva AS, Yunes JA, Gillies RJ, Gatenby RA. The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion. Cancer Res. 2009 Mar.69(6):2677-2684. Pubmedid: 19276380. Pmcid: PMC3718046.
  • Robey IF, Baggett BK, Kirkpatrick ND, Roe DJ, Dosescu J, Sloane BF, Hashim AI, Morse DL, Raghunand N, Gatenby RA, Gillies RJ. Bicarbonate increases tumor pH and inhibits spontaneous metastases. Cancer Res. 2009 Mar.69(6):2260-2268. Pubmedid: 19276390. Pmcid: PMC2834485.
  • Gatenby RA, Silva AS, Gillies RJ, Frieden BR. Adaptive therapy. Cancer Res. 2009 Jun.69(11):4894-4903. Pubmedid: 19487300. Pmcid: PMC3728826.
  • Aebersold R, Auffray C, Baney E, Barillot E, Brazma A, Brett C, Brunak S, Butte A, Califano A, Celis J, Cufer T, Ferrell J, Galas D, Gallahan D, Gatenby R, Goldbeter A, Hace N, Henney A, Hood L, Iyengar R, Jackson V, Kallioniemi O, Klingmüller U, Kolar P, Kolch W, Kyriakopoulou C, Laplace F, Lehrach H, Marcus F, Matrisian L, Nolan G, Pelkmans L, Potti A, Sander C, Seljak M, Singer D, Sorger P, Stunnenberg H, Superti-Furga G, Uhlen M, Vidal M, Weinstein J, Wigle D, Williams M, Wolkenhauer O, Zhivotovsky B, Zinovyev A, Zupan B. Report on EU-USA workshop: how systems biology can advance cancer research (27 October 2008). Mol Oncol. 2009 Feb.3(1):9-17. Pubmedid: 19383362. Pmcid: PMC2930781.
  • Krupinski EA, Patel B, Berger W, Hamilton AJ, Knapp AE, Becker GJ, Gatenby RA. Assessing radiology resident preparedness to manage IV contrast media reactions using simulation technology. Stud Health Technol Inform. 2009 Apr.142:139-141. Pubmedid: 19377133.
  • Gatenby R, Frieden B. Inducing catastrophe in malignant growth. Math Med Biol. 2008 Sep.25(3):267-283. Pubmedid: 18628244.
  • Fang JS, Gillies RD, Gatenby RA. Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression. Semin Cancer Biol. 2008 Oct.18(5):330-337. Pubmedid: 18455429. Pmcid: PMC2953714.
  • Huang L, Lai YC, Gatenby RA. Dynamics-based scalability of complex networks. Phys Rev E Stat Nonlin Soft Matter Phys. 2008 Oct.78(4 Pt 2):045102. Pubmedid: 18999478.
  • Frieden BR, Gatenby RA. Conditions for correspondence between Hartree scattering and biological growth. Phys Rev E. 2008 Oct.78(4 Pt 1):041902. Pubmedid: 18999450.
  • Smallbone K, Gatenby R, Maini P. Mathematical modelling of tumour acidity. J Theor Biol. 2008 Nov.255(1):106-112. Pubmedid: 18725231.
  • Huang L, Lai Y, Gatenby R. Optimization of synchronization in complex clustered networks. Chaos. 2008 Mar.18(1):013101-013101. Pubmedid: 18377052.
  • Gillies R, Robey I, Gatenby R. Causes and consequences of increased glucose metabolism of cancers. J Nucl Med. 2008 Jun.49 Suppl 2:24S-42S. Pubmedid: 18523064.
  • Gatenby R, Gillies R. A microenvironmental model of carcinogenesis. Nat Rev Cancer. 2008 Jan.8(1):56-61. Pubmedid: 18059462.
  • Huang L, Lai Y, Gatenby R. Alternating synchronizability of complex clustered networks with regular local structure. Phys Rev E. 2008 Jan.77(1 Pt 2):016103-016103. Pubmedid: 18351911.
  • Moellering R, Black K, Krishnamurty C, Baggett B, Stafford P, Rain M, Gatenby R, Gillies R. Acid treatment of melanoma cells selects for invasive phenotypes. Clin Exp Metastas. 2008 Aug.25(4):411-425. Pubmedid: 18301995.
  • Robey IF, Stephen RM, Brown KS, Baggett BK, Gatenby RA, Gillies RJ. Regulation of the Warburg effect in early-passage breast cancer cells. Neoplasia. 2008 Aug.10(8):745-756. Pubmedid: 18670636. Pmcid: PMC2481565.
  • Vincent T, Gatenby R. An evolutionary model for initiation, promotion, and progression in carcinogenesis. Int J Oncol. 2008 Apr.32(4):729-737. Pubmedid: 18360700.
  • Gatenby R, Smallbone K, Maini P, Rose F, Averill J, Nagle R, Worrall L, Gillies R. Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer. Brit J Cancer. 2007 Sep.97(5):646-653. Pubmedid: 17687336. Pmcid: PMC2360372.
  • Gatenby R, Gillies R. Glycolysis in cancer: a potential target for therapy. Int J Biochem Cell B. 2007 Oct.39(7-8):1358-1366. Pubmedid: 17499003.
  • Sanga S, Frieboes HB, Zheng X, Gatenby R, Bearer EL, Cristini V. Predictive oncology: a review of multidisciplinary, multiscale in silico modeling linking phenotype, morphology and growth. Neuroimage. 2007 Oct.37 Suppl 1:S120-S134. Pubmedid: 17629503. Pmcid: PMC2245890.
  • Gillies R, Gatenby R. Adaptive landscapes and emergent phenotypes: why do cancers have high glycolysis?. J Bioenerg Biomembr. 2007 Jun.39(3):251-257. Pubmedid: 17624581.
  • Gillies R, Gatenby R. Hypoxia and adaptive landscapes in the evolution of carcinogenesis. Cancer Metastasis Rev. 2007 Jun.26(2):311-317. Pubmedid: 17404691.
  • Smallbone K, Gatenby R, Gillies R, Maini P, Gavaghan D. Metabolic changes during carcinogenesis: potential impact on invasiveness. J Theor Biol. 2007 Feb.244(4):703-713. Pubmedid: 17055536.
  • Gatenby R, Frieden B. Information theory in living systems, methods, applications, and challenges. Bull Math Biol. 2007 Feb.69(2):635-657. Pubmedid: 17083004.
  • Gatenby RA. Commentary: carcinogenesis as Darwinian evolution? Do the math!. Int J Epidemiol. 2006 Oct.35(5):1165-1167. Pubmedid: 16990285.
  • Gatenby R, Gawlinski E, Gmitro A, Kaylor B, Gillies R. Acid-mediated tumor invasion: a multidisciplinary study. Cancer Res. 2006 May.66(10):5216-5223. Pubmedid: 16707446.
  • Frieboes HB, Zheng X, Sun CH, Tromberg B, Gatenby R, Cristini V. An integrated computational/experimental model of tumor invasion. Cancer Res. 2006 Feb.66(3):1597-1604. Pubmedid: 16452218.
  • Frieden BR, Gatenby RA. Power laws of complex systems from extreme physical information. Phys Rev E. 2005 Sep.72(3 Pt 2):036101. Pubmedid: 16241509.
  • Cristini V, Frieboes HB, Gatenby R, Caserta S, Ferrari M, Sinek J. Morphologic instability and cancer invasion. Clin Cancer Res. 2005 Oct.11(19 Pt 1):6772-6779. Pubmedid: 16203763.
  • Gatenby RA, Frieden BR. The role of non-genomic information in maintaining thermodynamic stability in living systems. Math Biosci Eng. 2005 Jan.2(1):43-51. Pubmedid: 20369911.
  • Smallbone K, Gavaghan D, Gatenby R, Maini P. The role of acidity in solid tumour growth and invasion. J Theor Biol. 2005 Aug.235(4):476-484. Pubmedid: 15935166.
  • Gillies R, Raghunand N, Garcia-Martin M, Gatenby R. pH imaging. A review of pH measurement methods and applications in cancers. Ieee Eng Med Biol Mag. 2004 Sep.23(5):57-64. Pubmedid: 15565800.
  • Gatenby R, Gillies R. Why do cancers have high aerobic glycolysis?. Nat Rev Cancer. 2004 Nov.4(11):891-899. Pubmedid: 15516961.
  • Gatenby R, Frieden B. Information dynamics in carcinogenesis and tumor growth. Mutat Res. 2004 Dec.568(2):259-273. Pubmedid: 15542113.
  • Gatenby RA, Vincent TL. Application of quantitative models from population biology and evolutionary game theory to tumor therapeutic strategies. Mol Cancer Ther. 2003 Sep.2(9):919-927. Pubmedid: 14555711.
  • Gatenby RA, Vincent TL. An evolutionary model of carcinogenesis. Cancer Res. 2003 Oct.63(19):6212-6220. Pubmedid: 14559806.
  • Gatenby R, Gawlinski E. The glycolytic phenotype in carcinogenesis and tumor invasion: insights through mathematical models. Cancer Res. 2003 Jul.63(14):3847-3854. Pubmedid: 12873971.
  • Gatenby R, Maini P. Mathematical oncology: cancer summed up. Nature. 2003 Jan.421(6921):321-321. Pubmedid: 12540881.
  • Raghunand N, Gatenby R, Gillies R. Microenvironmental and cellular consequences of altered blood flow in tumours. Br J Radiol. 2003 Dec.76 Spec No 1:S11-S22. Pubmedid: 15456710.
  • Raghunand N, Gatenby R, Gillies R. Microenvironmental cellular consequences of altered blood flow in tumours. Br J Radiol. 2003 Dec.76:S11-S22. Pubmedid: 15456710.
  • Gatenby R, Gawlinski E, Tangen C, Flanigan R, Crawford E. The possible role of postoperative azotemia in enhanced survival of patients with metastatic renal cancer after cytoreductive nephrectomy. Cancer Res. 2002 Sep.62(18):5218-5222. Pubmedid: 12234987.
  • Gatenby R, Frieden B. Application of information theory and extreme physical information to carcinogenesis. Cancer Res. 2002 Jul.62(13):3675-3684. Pubmedid: 12097274.
  • Gatenby R, Maini P. Modelling a new angle on understanding cancer. Nature. 2002 Dec.420(6915):462-462. Pubmedid: 12466818.
  • Gatenby R, Gawlinski E. Mathematical models of tumour invasion mediated by transformation-induced alteration of microenvironmental pH. Novartis Found Symp. 2001 Nov.240:85-96. Pubmedid: 11727939.
  • Patel A, Gawlinski E, Lemieux S, Gatenby R. A cellular automaton model of early tumor growth and invasion. J Theor Biol. 2001 Dec.213(3):315-331. Pubmedid: 11735284.
  • Stern R, Milestone B, Gatenby R. Carcinogenesis and the plasma membrane. Med Hypotheses. 1999 May.52(5):367-372. Pubmedid: 10416941.
  • Scott B, Gatenby R. Imaging advances in the diagnosis of endocrine neoplasia. Curr Opin Oncol. 1998 Jan.10(1):37-42. Pubmedid: 9466483.
  • Scott BA, Gatenby RA. Imaging advances in the diagnosis of endocrine neoplasia. Curr Opin Oncol. 1998 Jan.10(1):37-42. Pubmedid: 9466483.
  • Mercader V, Gatenby R, Mohr R, Fisher M, Caroline D. CT surveillance of the thorax in patients with squamous cell carcinoma of the head and neck: a preliminary experience. J Comput Assist Tomogr. 1997 May.21(3):412-417. Pubmedid: 9135650.
  • Mercader VP, Gatenby RA, Mohr RM, Fisher MS, Caroline DF. CT surveillance of the thorax in patients with squamous cell carcinoma of the head and neck: a preliminary experience. J Comput Assist Tomo. 1997 May.21(3):412-417. Pubmedid: 9135650.
  • Stemerman D, Caroline D, Dabezies M, Mercader V, Krevsky B, Gatenby R. Nonexpandable silicone esophageal stents for treatment of malignant tracheoesophageal fistulas: complications and radiographic appearances. Abdom Imaging. 1997 Jan.22(1):14-19. Pubmedid: 9000348 .
  • Stemerman DH, Caroline DF, Dabezies M, Mercader VP, Krevsky B, Gatenby RA. Nonexpandable silicone esophageal stents for treatment of malignant tracheoesophageal fistulas: complications and radiographic appearances. Abdom Imaging. 1997 Jan.22(1):14-19. Pubmedid: 9000348.
  • Kramer G, Gatenby R. Malignant plasmacytoma appearing as invasive paranasal sinus disease after cardiac transplantation. Ajnr Am J Neuroradiol. 1996 Sep.17(8):1582-1584. Pubmedid: 8883660 .
  • Kramer GS, Gatenby RA. Malignant plasmacytoma appearing as invasive paranasal sinus disease after cardiac transplantation. Ajnr Am J Neuroradiol. 1996 Sep.17(8):1582-1584. Pubmedid: 8883660. Pmcid: PMC8338725.
  • Gatenby R, Gawlinski E. A reaction-diffusion model of cancer invasion. Cancer Res. 1996 Dec.56(24):5745-5753. Pubmedid: 8971186 .
  • Gatenby R. Application of competition theory to tumour growth: implications for tumour biology and treatment. Eur J Cancer. 1996 Apr.32A(4):722-726. Pubmedid: 8695279 .
  • Stemerman D, Mercader V, Kramer G, Caroline D, Gatenby R. An unusual presentation of Zenker's diverticulum. Clin Imaging. 1996 Apr.20(2):112-114. Pubmedid: 8744819 .
  • Gatenby RA. Application of competition theory to tumour growth: implications for tumour biology and treatment. Eur J Cancer. 1996 Apr.32A(4):722-726. Pubmedid: 8695279.
  • Gatenby R, Seftor E, Hendrix M. Fibroblast Enhancement of Tumor Invasion in a Tumor-Host Interface Recapitulated in-vitro. Pathol Oncol Res. 1996.2(3):151-156. Pubmedid: 11173598.
  • Gatenby R. The potential role of transformation-induced metabolic changes in tumor-host interaction. Cancer Res. 1995 Sep.55(18):4151-4156. Pubmedid: 7664293 .
  • Gatenby RA. The potential role of transformation-induced metabolic changes in tumor-host interaction. Cancer Res. 1995 Sep.55(18):4151-4156. Pubmedid: 7664293.
  • Gatenby R. Models of tumor-host interaction as competing populations: implications for tumor biology and treatment. J Theor Biol. 1995 Oct.176(4):447-455. Pubmedid: 8551743 .
  • Gatenby R. Potential role of FDG-PET imaging in understanding tumor-host interaction. J Nucl Med. 1995 May.36(5):893-899. Pubmedid: 7738670 .
  • Gatenby RA. Potential role of FDG-PET imaging in understanding tumor-host interaction. J Nucl Med. 1995 May.36(5):893-899. Pubmedid: 7738670.
  • Gatenby R. The radiology of drug-induced disorders in the gastrointestinal tract. Semin Roentgenol. 1995 Jan.30(1):62-76. Review. Pubmedid: 7899884 .
  • Gatenby RA. The radiology of drug-induced disorders in the gastrointestinal tract. Semin Roentgenol. 1995 Jan.30(1):62-76. Pubmedid: 7899884.
  • Gatenby RA. Monitoring substrate uptake and distribution by tumors using percutaneous catheters and solid nuclear track detectors. Invest Radiol. 1994 Sep.29(9):834-838. Pubmedid: 7995702.
  • Unger E, Fritz T, Palestrant D, Meakem T, Granstrom P, Gatenby R. Preliminary evaluation of iron phytate (inositol hexaphosphate) as a gastrointestinal MR contrast agent. J Magn Reson Imaging. 1993 Jan.3(1):119-124. Pubmedid: 8428077 .
  • Unger E, Coia L, Gatenby R, Kessler H, Hartz W, Clair M, Broder G. CT staging of esophageal carcinoma in patients treated by primary radiationtherapy and chemotherapy. J Comput Assist Tomogr. 1992 Mar.16(2):235-239. Pubmedid: 1545019 .
  • Gatenby R, Taylor D, Ellison D. Identification of a novel cell population in nonhealing wounds in tumors. J Surg Res. 1992 Aug.53(2):188-194. Pubmedid: 1405608 .
  • Vanhoy JR, McEllistrem MT, Hicks SF, Gatenby RA, Baum EM, Johnson EL, Molnár G, Yates SW. Neutron and proton dynamics of 48Ca levels and gamma -ray decays from neutron inelastic scattering. Phys Rev C Nucl Phys. 1992 Apr.45(4):1628-1643. Pubmedid: 9967915.
  • Gatenby R. Population ecology issues in tumor growth. Cancer Res. 1991 May.51(10):2542-2547. Pubmedid: 2021934 .
  • Gatenby R, Hartz W, Kessler H. Percutaneous catheter drainage for malignant pericardial effusion. J Vasc Interv Radiol. 1991 Feb.2(1):151-155. Pubmedid: 1799745 .
  • Kessler H, Rimer B, Devine P, Gatenby R, Engstrom P. Corporate-sponsored breast cancer screening at the work site: results of a statewide program. Radiology. 1991 Apr.179(1):107-110. Pubmedid: 2006259 .
  • Kessler HB, Rimer BK, Devine PJ, Gatenby RA, Engstrom PF. Corporate-sponsored breast cancer screening at the work site: results of a statewide program. Radiology. 1991 Apr.179(1):107-110. Pubmedid: 2006259.
  • Keidan R, Solin L, Gatenby R, Weese J. CT-guided needle localization for intraoperative biopsy of the head and neck. Laryngoscope. 1990 Jan.100(1):97-98. Pubmedid: 2293708 .
  • Gatenby RA, Vanhoy JR, Baum EM, Johnson EL, Yates SW, Belgya T, Fazekas B, Veres Á, Molnár G. Fast E1 transitions and evidence for octupole-octupole and quadrupole-octupole excitations in 144Sm. Phys Rev C Nucl Phys. 1990 Feb.41(2):414-418. Pubmedid: 9966374.
  • Gatenby RA, Taylor DD. Suppression of wound healing in tumor bearing animals as a model for tumor-host interaction: mechanism of suppression. Cancer Res. 1990 Dec.50(24):7997-8001. Pubmedid: 2253242.
  • Keidan R, Fanning J, Gatenby R, Weese J. Recurrent typhlitis. A disease resulting from aggressive chemotherapy. Dis Colon Rectum. 1989 Mar.32(3):206-209. Pubmedid: 2920627 .
  • Keidan RD, Fanning J, Gatenby RA, Weese JL. Recurrent typhlitis. A disease resulting from aggressive chemotherapy. Dis Colon Rectum. 1989 Mar.32(3):206-209. Pubmedid: 2920627.
  • Ross G, Kessler H, Clair M, Gatenby R, Hartz W, Ross L. Sonographically guided paracentesis for palliation of symptomatic malignant ascites. Ajr Am J Roentgenol. 1989 Dec.153(6):1309-1311. Pubmedid: 2479242 .
  • Levine M, Ekberg O, Rubesin S, Gatenby R. Gastrointestinal sarcoidosis: radiographic findings. Ajr Am J Roentgenol. 1989 Aug.153(2):293-295. Pubmedid: 2750615 .
  • Levine MS, Ekberg O, Rubesin SE, Gatenby RA. Gastrointestinal sarcoidosis: radiographic findings. Ajr Am J Roentgenol. 1989 Aug.153(2):293-295. Pubmedid: 2750615.
  • Unger E, Winokur T, MacDougall P, Rosenblum J, Clair M, Gatenby R, TilcockC. Hepatic metastases: liposomal Gd-DTPA-enhanced MR imaging. Radiology. 1989 Apr.171(1):81-85. Pubmedid: 2928550 .
  • Moldofsky P, Rubenstein J, Richter M, Solin L, Gatenby R, Broder G. Quantitative lung scans for prediction of post-radiotherapy pulmonary function. Clin Nucl Med. 1988 Sep.13(9):644-646. Pubmedid: 3180610 .
  • Moldofsky PJ, Rubenstein JH, Richter MP, Solin LJ, Gatenby RA, Broder GJ. Quantitative lung scans for prediction of post-radiotherapy pulmonary function. Clin Nucl Med. 1988 Sep.13(9):644-646. Pubmedid: 3180610.
  • Weiner L, Moldofsky P, Gatenby R, O'Dwyer J, O'Brien J, Litwin S, ComisRL. Antibody delivery and effector cell activation in a phase II trial of recombinant gamma-interferon and the murine monoclonal antibody CO17-1A in advanced colorectal carcinoma. Cancer Res. 1988 May.48(9):2568-2573. Pubmedid: 3128400 .
  • Gatenby R, Kessler H, Rosenblum J, Coia L, Moldofsky P, Hartz W, BroderGJ. Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy. Int J Radiat Oncol Biol Phys. 1988 May.14(5):831-838. Pubmedid: 3360652 .
  • Gatenby RA, Kessler HB, Rosenblum JS, Coia LR, Moldofsky PJ, Hartz WH, Broder GJ. Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy. Int J Radiat Oncol Biol Phys. 1988 May.14(5):831-838. Pubmedid: 3360652.
  • Weiner LM, Moldofsky PJ, Gatenby RA, O'Dwyer J, O'Brien J, Litwin S, Comis RL. Antibody delivery and effector cell activation in a phase II trial of recombinant gamma-interferon and the murine monoclonal antibody CO17-1A in advanced colorectal carcinoma. Cancer Res. 1988 May.48(9):2568-2573. Pubmedid: 3128400.
  • Unger E, Moldofsky P, Gatenby R, Hartz W, Broder G. Diagnosis of osteomyelitis by MR imaging. Ajr Am J Roentgenol. 1988 Mar.150(3):605-610. Pubmedid: 3257618 .
  • Gatenby R, Moldofsky P, Weiner L. Metastatic colon cancer: correlation of oxygen levels with I-131 F(ab')2 uptake. Radiology. 1988 Mar.166(3):757-759. Pubmedid: 3340773 .
  • Gatenby RA, Moldofsky PJ, Weiner LM. Metastatic colon cancer: correlation of oxygen levels with I-131 F(ab')2 uptake. Radiology. 1988 Mar.166(3):757-759. Pubmedid: 3340773.
  • Unger E, Cohen M, Gatenby R, Clair M, Brown T, Nelson S, McGlone J. Single breath-holding scans of the abdomen using FISP and FLASH at 1.5 T. J Comput Assist Tomogr. 1988 Jul.12(4):575-583. Pubmedid: 3392256 .
  • Unger EC, Cohen MS, Gatenby RA, Clair MR, Brown TR, Nelson SJ, McGlone JS. Single breath-holding scans of the abdomen using FISP and FLASH at 1.5 T. J Comput Assist Tomo. 1988 Jul.12(4):575-583. Pubmedid: 3392256.
  • Molnár G, Gatenby RA, Yates SW. Search for mixed-symmetry states in the O(6) nucleus 134Ba. Phys Rev C Nucl Phys. 1988 Feb.37(2):898-901. Pubmedid: 9954520.
  • Gatenby R, Brown T. Tumor oxygenation using direct injection of oxygenated saline. Invest Radiol. 1987 May.22(5):404-407. Pubmedid: 3597008 .
  • Gatenby RA, Brown TR. Tumor oxygenation using direct injection of oxygenated saline. Invest Radiol. 1987 May.22(5):404-407. Pubmedid: 3597008.
  • Gatenby R, Hammond N, Brown D. Tumor therapy with hematoporphyrin derivative and lasers via a percutaneous fiberoptic technique: preclinical experiments. Radiology. 1987 Apr.163(1):167-171. Pubmedid: 3823432 .
  • Gatenby R, Hartz W, Engstrom P, Rosenblum J, Hammond N, Kessler H, Moldofsky P, Clair M, Unger E, Broder G. CT-guided laser therapy in resistant human tumors: phase I clinical trials. Radiology. 1987 Apr.163(1):172-175. Pubmedid: 3823433 .
  • Gatenby R, Rosenblum J, Leonard C, Moldofsky P, Broder G. Esophageal speech: double-contrast evaluation of the pharyngo-esophageal segment. Radiology. 1985 Oct.157(1):127-131. Pubmedid: 4034957 .
  • Gatenby R, Mulhern CB J, Strawitz J, Moldofsky P. Comparison of clinical and computed tomographic staging of head and neck tumors. Ajnr Am J Neuroradiol. 1985 May.6(3):399-401. Pubmedid: 3923796 .
  • Gatenby RA, Mulhern CB, Strawitz J, Moldofsky PJ. Comparison of clinical and computed tomographic staging of head and neck tumors. Ajnr Am J Neuroradiol. 1985 May.6(3):399-401. Pubmedid: 3923796. Pmcid: PMC8335341.
  • Gatenby R, Coia L, Richter M, Katz H, Moldofsky P, Engstrom P, Brown D, Brookland R, Broder G. Oxygen tension in human tumors: in vivo mapping using CT-guided probes. Radiology. 1985 Jul.156(1):211-214. Pubmedid: 4001408 .
  • Gatenby RA, Coia LR, Richter MP, Katz H, Moldofsky PJ, Engstrom P, Brown DQ, Brookland R, Broder GJ. Oxygen tension in human tumors: in vivo mapping using CT-guided probes. Radiology. 1985 Jul.156(1):211-214. Pubmedid: 4001408.
  • Hartz W, Gatenby R. Interventional radiology in palliative care. Semin Oncol. 1985 Dec.12(4):390-393. Pubmedid: 2417324 .
  • Hartz WH, Gatenby RA. Interventional radiology in palliative care. Semin Oncol. 1985 Dec.12(4):390-393. Pubmedid: 2417324.
  • Gatenby R, Mulhern CB J, Richter M, Moldofsky P. CT-guided biopsy for the detection and staging of tumors of the head and neck. Ajnr Am J Neuroradiol. 1984 May.5(3):287-290. Pubmedid: 6426282 .
  • Gatenby RA, Mulhern CB, Richter MP, Moldofsky PJ. CT-guided biopsy for the detection and staging of tumors of the head and neck. Ajnr Am J Neuroradiol. 1984 May.5(3):287-290. Pubmedid: 6426282. Pmcid: PMC8334135.
  • Moldofsky P, Sears H, Mulhern CB J, Hammond N, Powe J, Gatenby R, Steplewski Z, Koprowski H. Detection of metastatic tumor in normal-sized retroperitoneal lymph nodes by monoclonal-antibody imaging. N Engl J Med. 1984 Jul.311(2):106-107. Pubmedid: 6738588 .
  • Gatenby R, Mulhern CB J, Broder G, Moldofsky P. Computed-tomographic-guided biopsy of small apical and peripheral upper-lobe lung masses. Radiology. 1984 Feb.150(2):591-592. Pubmedid: 6691121 .
  • Gatenby RA, Mulhern CB, Broder GJ, Moldofsky PJ. Computed-tomographic-guided biopsy of small apical and peripheral upper-lobe lung masses. Radiology. 1984 Feb.150(2):591-592. Pubmedid: 6691121.
  • Gatenby R, Mulhern CB J, Moldofsky P. Computed tomography guided thin needle biopsy of small lytic bone lesions. Skeletal Radiol. 1984.11(4):289-291. Pubmedid: 6729503 .
  • Gatenby RA, Mulhern CB, Moldofsky PJ. Computed tomography guided thin needle biopsy of small lytic bone lesions. Skeletal Radiol. 1984.11(4):289-291. Pubmedid: 6729503.
  • Moldofsky P, Powe J, Mulhern CB J, Hammond N, Sears H, Gatenby R, Steplewski Z, Koprowski H. Metastatic colon carcinoma detected with radiolabeled F(ab')2 monoclonal antibody fragments. Radiology. 1983 Nov.149(2):549-555. Pubmedid: 6622704 .
  • Moldofsky PJ, Powe J, Mulhern CB, Hammond N, Sears HF, Gatenby RA, Steplewski Z, Koprowski H. Metastatic colon carcinoma detected with radiolabeled F(ab')2 monoclonal antibody fragments. Radiology. 1983 Nov.149(2):549-555. Pubmedid: 6622704.
  • Creteur V, Laufer I, Kressel H, Caroline D, Goren R, Evers K, Glick S, Gatenby R. Drug-induced esophagitis detected by double-contrast radiography. Radiology. 1983 May.147(2):365-368. Pubmedid: 6836116 .
  • Creteur V, Laufer I, Kressel HY, Caroline DF, Goren RA, Evers KA, Glick SN, Gatenby RA. Drug-induced esophagitis detected by double-contrast radiography. Radiology. 1983 May.147(2):365-368. Pubmedid: 6836116.
  • Gatenby R, Mulhern CB J, Strawitz J. CT-guided percutaneous biopsies of head and neck masses. Radiology. 1983 Mar.146(3):717-719. Pubmedid: 6828687 .
  • Gatenby RA, Mulhern CB, Strawitz J. CT-guided percutaneous biopsies of head and neck masses. Radiology. 1983 Mar.146(3):717-719. Pubmedid: 6828687.
  • Gatenby R. Diagnostic evaluation of a renal mass. Semin Oncol. 1983 Dec.10(4):401-412. Pubmedid: 6665567 .
  • Gatenby RA. Diagnostic evaluation of a renal mass. Semin Oncol. 1983 Dec.10(4):401-412. Pubmedid: 6665567.
  • Kressel H, Gatenby R, Troupin R, Golden D. Correlative imaging conference: Hospital of the University of Pennsylvania. V.Left upper quadrant mass in pregnancy. Ajr Am J Roentgenol. 1982 Jul.139(1):87-91. Pubmedid: 6979871 .
  • Kressel HY, Gatenby RA, Troupin RH, Golden DA. Correlative imaging conference: Hospital of the University of Pennsylvania. V. Left upper quadrant mass in pregnancy. Ajr Am J Roentgenol. 1982 Jul.139(1):87-91. Pubmedid: 6979871.
  • Kressel H, Gatenby R, Troupin R. Correlative imaging conference: Hospital of the University of Pennsylvania.Abdominal pain and blood loss. Ajr Am J Roentgenol. 1981 Oct.137(4):769-775. Pubmedid: 6974974 .
  • Kressel HY, Gatenby RA, Troupin RH. Correlative imaging conference: Hospital of the University of Pennsylvania. Abdominal pain and blood loss. Ajr Am J Roentgenol. 1981 Oct.137(4):769-775. Pubmedid: 6974974.
  • Freiman D, Spence R, Gatenby R, Gertner M, Roberts B, Berkowitz H, Ring E, Oleaga J. Transluminal angioplasty of the iliac and femoral arteries: follow-up results without anticoagulation. Radiology. 1981 Nov.141(2):347-350. Pubmedid: 6457315 .
  • Spence R, Freiman D, Gatenby R, Hobbs C, Barker C, Berkowitz H, RobertsB, McClean G, Oleaga J, Ring E. Long-term results of transluminal angioplasty of the iliac and femoral arteries. Arch Surg. 1981 Nov.116(11):1377-1386. Pubmedid: 6458256 .
  • McGlynn TJ J, Burnside J, Gatenby R. Symptomatic abdominal bronchogenic cyst mimicking acute ischemic heart disease. Heart Lung. 1981 Jan.10(1):109-111. Pubmedid: 6905820 .

Grants

Title: Eco-Evolutionary Dynamics of NSCLC to Immunotherapy: Response and Resistance
Sponsor: Nat Institutes of Health
PI (Contact): Anderson, A., PI (MPI): Gatenby, R.

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